<?xml version="1.0" encoding="SHIFT_JIS" standalone="no"?>
<!DOCTYPE sanac PUBLIC "sanac" "sanac.dtd">
<sanac frame="CADLIVE" frameInfo="2.15">
<model name="Drosophila-Circadian" modelInfo="">
<panel size="1600" magnification="100"/>
<listOfCompartments numberOfCompartments="3">
<compartment name="environment" volume="" R="255" G="255" B="255">
<subCompartment id="1" cat="Square" cx="-100" cy="-100" l="-1" h="80" w="80"/>
</compartment>
<compartment name="cytoplasm" volume="" R="224" G="224" B="255">
<subCompartment id="2" cat="Square" cx="420" cy="384" l="404" h="736" w="808"/>
</compartment>
<compartment name="nucleoplasm" volume="" R="224" G="255" B="224">
<subCompartment id="3" cat="Circle" cx="496" cy="416" l="316" h="-4" w="632"/>
</compartment>
</listOfCompartments>
<listOfSpecies numberOfSpecies="38">
<Specie specieID="1" name="PER" compartment="cytoplasm">
<specieAttribute specieClass="protein" massBalance="on" totalAmount="variable" decomposition="on" initialAmount="" isVisible="true"/>
</Specie>
<Specie specieID="2" name="PER-P" compartment="cytoplasm">
<specieAttribute specieClass="modified" massBalance="on" totalAmount="variable" decomposition="on" initialAmount="" isVisible="true"/>
</Specie>
<Specie specieID="4" name="PER-P-P" compartment="cytoplasm">
<specieAttribute specieClass="modified" massBalance="on" totalAmount="variable" decomposition="on" initialAmount="" isVisible="true"/>
</Specie>
<Specie specieID="6" name="TIM" compartment="cytoplasm">
<specieAttribute specieClass="protein" massBalance="on" totalAmount="variable" decomposition="on" initialAmount="" isVisible="true"/>
</Specie>
<Specie specieID="8" name="DBT" compartment="cytoplasm">
<specieAttribute specieClass="protein" massBalance="on" totalAmount="variable" decomposition="on" initialAmount="" isVisible="true"/>
</Specie>
<Specie specieID="12" name="CHAN" compartment="nucleoplasm">
<specieAttribute specieClass="protein" massBalance="on" totalAmount="variable" decomposition="on" initialAmount="" isVisible="true"/>
</Specie>
<Specie specieID="16" name="CLK" compartment="nucleoplasm">
<specieAttribute specieClass="protein" massBalance="on" totalAmount="variable" decomposition="on" initialAmount="" isVisible="true"/>
</Specie>
<Specie specieID="17" name="CYC" compartment="nucleoplasm">
<specieAttribute specieClass="protein" massBalance="on" totalAmount="variable" decomposition="on" initialAmount="" isVisible="true"/>
</Specie>
<Specie specieID="20" name="REP" compartment="nucleoplasm">
<specieAttribute specieClass="protein" massBalance="on" totalAmount="variable" decomposition="on" initialAmount="" isVisible="true"/>
</Specie>
<Specie specieID="22" name="Promoter(CLK)" compartment="nucleoplasm">
<specieAttribute specieClass="DNA_promoter" massBalance="on" totalAmount="constant" decomposition="off" initialAmount="" isVisible="true"/>
</Specie>
<Specie specieID="24" name="Gene(CLK)" compartment="nucleoplasm">
<specieAttribute specieClass="DNA_gene" massBalance="off" totalAmount="constant" decomposition="off" initialAmount="" isVisible="true"/>
</Specie>
<Specie specieID="25" name="mRNA(CLK)" compartment="nucleoplasm">
<specieAttribute specieClass="RNA" massBalance="off" totalAmount="variable" decomposition="on" initialAmount="" isVisible="true"/>
</Specie>
<Specie specieID="26" name="Gene(PER)" compartment="nucleoplasm">
<specieAttribute specieClass="DNA_gene" massBalance="off" totalAmount="constant" decomposition="off" initialAmount="" isVisible="true"/>
</Specie>
<Specie specieID="27" name="mRNA(PER)" compartment="nucleoplasm">
<specieAttribute specieClass="RNA" massBalance="off" totalAmount="variable" decomposition="on" initialAmount="" isVisible="true"/>
</Specie>
<Specie specieID="28" name="Enhancer(PER)" compartment="nucleoplasm">
<specieAttribute specieClass="DNA_enhancer" massBalance="on" totalAmount="constant" decomposition="off" initialAmount="" isVisible="true"/>
</Specie>
<Specie specieID="30" name="Enhancer(TIM)" compartment="nucleoplasm">
<specieAttribute specieClass="DNA_enhancer" massBalance="on" totalAmount="constant" decomposition="off" initialAmount="" isVisible="true"/>
</Specie>
<Specie specieID="32" name="Gene(TIM)" compartment="nucleoplasm">
<specieAttribute specieClass="DNA_gene" massBalance="off" totalAmount="constant" decomposition="off" initialAmount="" isVisible="true"/>
</Specie>
<Specie specieID="33" name="mRNA(TIM)" compartment="nucleoplasm">
<specieAttribute specieClass="RNA" massBalance="off" totalAmount="variable" decomposition="on" initialAmount="" isVisible="true"/>
</Specie>
<Specie specieID="34" name="Gene(DBT)" compartment="nucleoplasm">
<specieAttribute specieClass="DNA_gene" massBalance="off" totalAmount="constant" decomposition="off" initialAmount="" isVisible="true"/>
</Specie>
<Specie specieID="35" name="mRNA(DBT)" compartment="nucleoplasm">
<specieAttribute specieClass="RNA" massBalance="off" totalAmount="variable" decomposition="on" initialAmount="" isVisible="true"/>
</Specie>
<Specie specieID="36" name="Gene(CHAN)" compartment="nucleoplasm">
<specieAttribute specieClass="DNA_gene" massBalance="off" totalAmount="constant" decomposition="off" initialAmount="" isVisible="true"/>
</Specie>
<Specie specieID="37" name="mRNA(CHAN)" compartment="nucleoplasm">
<specieAttribute specieClass="RNA" massBalance="off" totalAmount="variable" decomposition="on" initialAmount="" isVisible="true"/>
</Specie>
<Specie specieID="38" name="Gene(REP)" compartment="nucleoplasm">
<specieAttribute specieClass="DNA_gene" massBalance="off" totalAmount="constant" decomposition="off" initialAmount="" isVisible="true"/>
</Specie>
<Specie specieID="39" name="mRNA(REP)" compartment="nucleoplasm">
<specieAttribute specieClass="RNA" massBalance="off" totalAmount="variable" decomposition="on" initialAmount="" isVisible="true"/>
</Specie>
<Specie specieID="49" name="Gene(CYC)" compartment="nucleoplasm">
<specieAttribute specieClass="DNA_gene" massBalance="off" totalAmount="constant" decomposition="off" initialAmount="" isVisible="true"/>
</Specie>
<Specie specieID="50" name="mRNA(CYC)" compartment="nucleoplasm">
<specieAttribute specieClass="RNA" massBalance="off" totalAmount="variable" decomposition="on" initialAmount="" isVisible="true"/>
</Specie>
<Specie specieID="57" name="PER-N-TIM" compartment="nucleoplasm">
<specieAttribute specieClass="protein" massBalance="on" totalAmount="variable" decomposition="on" initialAmount="" isVisible="true"/>
</Specie>
<Specie specieID="59" name="P" compartment="cytoplasm">
<specieAttribute specieClass="text_option" massBalance="off" totalAmount="constant" decomposition="off" initialAmount="" isVisible="true"/>
</Specie>
<Specie specieID="9" name="PER-P:P:DBT" compartment="cytoplasm">
<specieAttribute specieClass="modifier_complex" massBalance="on" totalAmount="variable" decomposition="on" initialAmount="" isVisible="false"/>
<listOfElements numberOfElements="3">
<specieReference specieID="2" name="PER-P" compartment="cytoplasm" stoichiometry="1" cx="80" cy="382"/>
<specieReference specieID="59" name="P" compartment="cytoplasm" stoichiometry="1" cx="-1" cy="-1"/>
<specieReference specieID="8" name="DBT" compartment="cytoplasm" stoichiometry="1" cx="135" cy="431"/>
</listOfElements>
</Specie>
<Specie specieID="10" name="PER:P:DBT" compartment="cytoplasm">
<specieAttribute specieClass="modifier_complex" massBalance="on" totalAmount="variable" decomposition="on" initialAmount="" isVisible="false"/>
<listOfElements numberOfElements="3">
<specieReference specieID="1" name="PER" compartment="cytoplasm" stoichiometry="1" cx="80" cy="696"/>
<specieReference specieID="59" name="P" compartment="cytoplasm" stoichiometry="1" cx="-1" cy="-1"/>
<specieReference specieID="8" name="DBT" compartment="cytoplasm" stoichiometry="1" cx="135" cy="431"/>
</listOfElements>
</Specie>
<Specie specieID="18" name="CLK:CYC" compartment="nucleoplasm">
<specieAttribute specieClass="complex" massBalance="off" totalAmount="variable" decomposition="on" initialAmount="" isVisible="true"/>
<listOfElements numberOfElements="2">
<specieReference specieID="16" name="CLK" compartment="nucleoplasm" stoichiometry="1" cx="738" cy="331"/>
<specieReference specieID="17" name="CYC" compartment="nucleoplasm" stoichiometry="1" cx="266" cy="331"/>
</listOfElements>
</Specie>
<Specie specieID="19" name="CLK:CYC:PER-N-TIM" compartment="nucleoplasm">
<specieAttribute specieClass="complex" massBalance="off" totalAmount="variable" decomposition="on" isVisible="true"/>
<listOfElements numberOfElements="2">
<specieReference specieID="18" name="CLK:CYC" compartment="nucleoplasm" stoichiometry="1" cx="495" cy="331"/>
<specieReference specieID="57" name="PER-N-TIM" compartment="nucleoplasm" stoichiometry="1" cx="495" cy="165"/>
</listOfElements>
</Specie>
<Specie specieID="21" name="CLK:CYC:REP" compartment="nucleoplasm">
<specieAttribute specieClass="complex" massBalance="off" totalAmount="variable" decomposition="on" initialAmount="" isVisible="true"/>
<listOfElements numberOfElements="2">
<specieReference specieID="18" name="CLK:CYC" compartment="nucleoplasm" stoichiometry="1" cx="495" cy="331"/>
<specieReference specieID="20" name="REP" compartment="nucleoplasm" stoichiometry="1" cx="495" cy="589"/>
</listOfElements>
</Specie>
<Specie specieID="29" name="CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:Enhancer(PER)" compartment="nucleoplasm">
<specieAttribute specieClass="complex" massBalance="off" totalAmount="variable" decomposition="on" initialAmount="" isVisible="true"/>
<listOfElements numberOfElements="2">
<specieReference specieID="18" name="CLK:CYC" compartment="nucleoplasm" stoichiometry="10" cx="495" cy="331"/>
<specieReference specieID="28" name="Enhancer(PER)" compartment="nucleoplasm" stoichiometry="1" cx="305" cy="535"/>
</listOfElements>
</Specie>
<Specie specieID="31" name="CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:Enhancer(TIM)" compartment="nucleoplasm">
<specieAttribute specieClass="complex" massBalance="off" totalAmount="variable" decomposition="on" initialAmount="" isVisible="true"/>
<listOfElements numberOfElements="2">
<specieReference specieID="18" name="CLK:CYC" compartment="nucleoplasm" stoichiometry="10" cx="495" cy="331"/>
<specieReference specieID="30" name="Enhancer(TIM)" compartment="nucleoplasm" stoichiometry="1" cx="590" cy="283"/>
</listOfElements>
</Specie>
<Specie specieID="42" name="PER-P-P:TIM" compartment="cytoplasm">
<specieAttribute specieClass="complex" massBalance="off" totalAmount="variable" decomposition="on" initialAmount="" isVisible="true"/>
<listOfElements numberOfElements="2">
<specieReference specieID="4" name="PER-P-P" compartment="cytoplasm" stoichiometry="1" cx="80" cy="66"/>
<specieReference specieID="6" name="TIM" compartment="cytoplasm" stoichiometry="1" cx="719" cy="66"/>
</listOfElements>
</Specie>
<Specie specieID="45" name="CLK:CYC:REP:CLK:CYC:REP:CLK:CYC:REP:CLK:CYC:REP:CLK:CYC:REP:CLK:CYC:REP:CLK:CYC:REP:CLK:CYC:REP:CLK:CYC:REP:CLK:CYC:REP:Promoter(CLK)" compartment="nucleoplasm">
<specieAttribute specieClass="complex" massBalance="off" totalAmount="variable" decomposition="on" initialAmount="" isVisible="true"/>
<listOfElements numberOfElements="2">
<specieReference specieID="21" name="CLK:CYC:REP" compartment="nucleoplasm" stoichiometry="10" cx="495" cy="489"/>
<specieReference specieID="22" name="Promoter(CLK)" compartment="nucleoplasm" stoichiometry="1" cx="610" cy="542"/>
</listOfElements>
</Specie>
<Specie specieID="58" name="PER-P-P:TIM:CHAN" compartment="nucleoplasm">
<specieAttribute specieClass="modifier_complex" massBalance="on" totalAmount="variable" decomposition="on" initialAmount="" isVisible="false"/>
<listOfElements numberOfElements="2">
<specieReference specieID="42" name="PER-P-P:TIM" compartment="cytoplasm" stoichiometry="1" cx="495" cy="66"/>
<specieReference specieID="12" name="CHAN" compartment="nucleoplasm" stoichiometry="1" cx="425" cy="141"/>
</listOfElements>
</Specie>
</listOfSpecies>
<listOfReactions layer="gene" numberOfReactions="14">
<Reaction reactionID="36" groupID="15" reactionType="transcription" isConvertible="true" reactionName="#36" isVisible="true" modifierReactionEquation="CLK:CYC:REP:CLK:CYC:REP:CLK:CYC:REP:CLK:CYC:REP:CLK:CYC:REP:CLK:CYC:REP:CLK:CYC:REP:CLK:CYC:REP:CLK:CYC:REP:CLK:CYC:REP:Promoter(CLK) -|| Gene(CLK) -&gt; mRNA(CLK)">
<listOfReactants numberOfReactants="1">
<specieReference specieID="24" name="Gene(CLK)" compartment="nucleoplasm" stoichiometry="1" cx="716" cy="541"/>
</listOfReactants>
<listOfProducts numberOfProducts="1">
<specieReference specieID="25" name="mRNA(CLK)" compartment="nucleoplasm" stoichiometry="1" cx="738" cy="442"/>
</listOfProducts>
<listOfModifiers numberOfModifiers="1">
<modifierSpecieReference specieID="45" name="CLK:CYC:REP:CLK:CYC:REP:CLK:CYC:REP:CLK:CYC:REP:CLK:CYC:REP:CLK:CYC:REP:CLK:CYC:REP:CLK:CYC:REP:CLK:CYC:REP:CLK:CYC:REP:Promoter(CLK)" compartment="nucleoplasm" stoichiometry="1" cx="610" cy="489" modifierType="inhibitor" isTotal="true">
<lineLocation index="0" x1="610" y1="489" x2="738" y2="489" connectSegmentPoint="0"/>
</modifierSpecieReference>
</listOfModifiers>
<lineLocation index="0" x1="738" y1="527" x2="738" y2="442" connectSegmentPoint="0"/>
</Reaction>
<Reaction reactionID="17" groupID="17" reactionType="translation" isConvertible="true" reactionName="#17" isVisible="true" modifierReactionEquation="mRNA(CLK) -&gt; CLK">
<listOfReactants numberOfReactants="1">
<specieReference specieID="25" name="mRNA(CLK)" compartment="nucleoplasm" stoichiometry="1" cx="738" cy="442"/>
</listOfReactants>
<listOfProducts numberOfProducts="1">
<specieReference specieID="16" name="CLK" compartment="nucleoplasm" stoichiometry="1" cx="738" cy="331"/>
</listOfProducts>
<lineLocation index="0" x1="738" y1="442" x2="738" y2="331" connectSegmentPoint="0"/>
</Reaction>
<Reaction reactionID="21" groupID="18" reactionType="transcription" isConvertible="true" reactionName="#21" isVisible="true" modifierReactionEquation="CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:Enhancer(PER) -&gt;&gt; Gene(PER) -&gt; mRNA(PER)">
<listOfReactants numberOfReactants="1">
<specieReference specieID="26" name="Gene(PER)" compartment="nucleoplasm" stoichiometry="1" cx="411" cy="593"/>
</listOfReactants>
<listOfProducts numberOfProducts="1">
<specieReference specieID="27" name="mRNA(PER)" compartment="nucleoplasm" stoichiometry="1" cx="327" cy="579"/>
</listOfProducts>
<listOfModifiers numberOfModifiers="1">
<modifierSpecieReference specieID="29" name="CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:Enhancer(PER)" compartment="nucleoplasm" stoichiometry="1" cx="392" cy="491" modifierType="activator" isTotal="true">
<lineLocation index="0" x1="392" y1="491" x2="392" y2="579" connectSegmentPoint="0"/>
</modifierSpecieReference>
</listOfModifiers>
<lineLocation index="0" x1="433" y1="579" x2="327" y2="579" connectSegmentPoint="0"/>
</Reaction>
<Reaction reactionID="22" groupID="22" reactionType="translation" isConvertible="true" reactionName="#22" isVisible="true" modifierReactionEquation="mRNA(PER) -&gt; PER">
<listOfReactants numberOfReactants="1">
<specieReference specieID="27" name="mRNA(PER)" compartment="nucleoplasm" stoichiometry="1" cx="327" cy="579"/>
</listOfReactants>
<listOfProducts numberOfProducts="1">
<specieReference specieID="1" name="PER" compartment="cytoplasm" stoichiometry="1" cx="80" cy="696"/>
</listOfProducts>
<lineLocation index="0" x1="327" y1="579" x2="80" y2="696" connectSegmentPoint="0">
<segmentStatus counter="1" x="327" y="696"/>
</lineLocation>
</Reaction>
<Reaction reactionID="26" groupID="25" reactionType="transcription" isConvertible="true" reactionName="#26" isVisible="true" modifierReactionEquation="CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:Enhancer(TIM) -&gt;&gt; Gene(TIM) -&gt; mRNA(TIM)">
<listOfReactants numberOfReactants="1">
<specieReference specieID="32" name="Gene(TIM)" compartment="nucleoplasm" stoichiometry="1" cx="647" cy="259"/>
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<listOfProducts numberOfProducts="1">
<specieReference specieID="33" name="mRNA(TIM)" compartment="nucleoplasm" stoichiometry="1" cx="719" cy="245"/>
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<listOfModifiers numberOfModifiers="1">
<modifierSpecieReference specieID="31" name="CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:Enhancer(TIM)" compartment="nucleoplasm" stoichiometry="1" cx="590" cy="211" modifierType="activator" isTotal="true">
<lineLocation index="0" x1="590" y1="211" x2="681" y2="245" connectSegmentPoint="0">
<segmentStatus counter="1" x="681" y="211"/>
</lineLocation>
</modifierSpecieReference>
</listOfModifiers>
<lineLocation index="0" x1="669" y1="245" x2="719" y2="245" connectSegmentPoint="0"/>
</Reaction>
<Reaction reactionID="28" groupID="28" reactionType="translation" isConvertible="true" reactionName="#28" isVisible="true" modifierReactionEquation="mRNA(TIM) -&gt; TIM">
<listOfReactants numberOfReactants="1">
<specieReference specieID="33" name="mRNA(TIM)" compartment="nucleoplasm" stoichiometry="1" cx="719" cy="245"/>
</listOfReactants>
<listOfProducts numberOfProducts="1">
<specieReference specieID="6" name="TIM" compartment="cytoplasm" stoichiometry="1" cx="719" cy="66"/>
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<lineLocation index="0" x1="719" y1="245" x2="719" y2="66" connectSegmentPoint="0"/>
</Reaction>
<Reaction reactionID="29" groupID="29" reactionType="transcription" isConvertible="true" reactionName="#29" isVisible="true" modifierReactionEquation="Gene(DBT) -&gt; mRNA(DBT)">
<listOfReactants numberOfReactants="1">
<specieReference specieID="34" name="Gene(DBT)" compartment="nucleoplasm" stoichiometry="1" cx="228" cy="472"/>
</listOfReactants>
<listOfProducts numberOfProducts="1">
<specieReference specieID="35" name="mRNA(DBT)" compartment="nucleoplasm" stoichiometry="1" cx="250" cy="431"/>
</listOfProducts>
<lineLocation index="0" x1="250" y1="458" x2="250" y2="431" connectSegmentPoint="0"/>
</Reaction>
<Reaction reactionID="30" groupID="30" reactionType="translation" isConvertible="true" reactionName="#30" isVisible="true" modifierReactionEquation="mRNA(DBT) -&gt; DBT">
<listOfReactants numberOfReactants="1">
<specieReference specieID="35" name="mRNA(DBT)" compartment="nucleoplasm" stoichiometry="1" cx="250" cy="431"/>
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<listOfProducts numberOfProducts="1">
<specieReference specieID="8" name="DBT" compartment="cytoplasm" stoichiometry="1" cx="135" cy="431"/>
</listOfProducts>
<lineLocation index="0" x1="250" y1="431" x2="135" y2="431" connectSegmentPoint="0"/>
</Reaction>
<Reaction reactionID="31" groupID="31" reactionType="transcription" isConvertible="true" reactionName="#31" isVisible="true" modifierReactionEquation="Gene(CHAN) -&gt; mRNA(CHAN)">
<listOfReactants numberOfReactants="1">
<specieReference specieID="36" name="Gene(CHAN)" compartment="nucleoplasm" stoichiometry="1" cx="334" cy="236"/>
</listOfReactants>
<listOfProducts numberOfProducts="1">
<specieReference specieID="37" name="mRNA(CHAN)" compartment="nucleoplasm" stoichiometry="1" cx="425" cy="222"/>
</listOfProducts>
<lineLocation index="0" x1="356" y1="222" x2="425" y2="222" connectSegmentPoint="0"/>
</Reaction>
<Reaction reactionID="32" groupID="32" reactionType="translation" isConvertible="true" reactionName="#32" isVisible="true" modifierReactionEquation="mRNA(CHAN) -&gt; CHAN">
<listOfReactants numberOfReactants="1">
<specieReference specieID="37" name="mRNA(CHAN)" compartment="nucleoplasm" stoichiometry="1" cx="425" cy="222"/>
</listOfReactants>
<listOfProducts numberOfProducts="1">
<specieReference specieID="12" name="CHAN" compartment="nucleoplasm" stoichiometry="1" cx="425" cy="141"/>
</listOfProducts>
<lineLocation index="0" x1="425" y1="222" x2="425" y2="141" connectSegmentPoint="0"/>
</Reaction>
<Reaction reactionID="33" groupID="33" reactionType="transcription" isConvertible="true" reactionName="#33" isVisible="true" modifierReactionEquation="Gene(REP) -&gt; mRNA(REP)">
<listOfReactants numberOfReactants="1">
<specieReference specieID="38" name="Gene(REP)" compartment="nucleoplasm" stoichiometry="1" cx="410" cy="684"/>
</listOfReactants>
<listOfProducts numberOfProducts="1">
<specieReference specieID="39" name="mRNA(REP)" compartment="nucleoplasm" stoichiometry="1" cx="495" cy="670"/>
</listOfProducts>
<lineLocation index="0" x1="432" y1="670" x2="495" y2="670" connectSegmentPoint="0"/>
</Reaction>
<Reaction reactionID="34" groupID="34" reactionType="translation" isConvertible="true" reactionName="#34" isVisible="true" modifierReactionEquation="mRNA(REP) -&gt; REP">
<listOfReactants numberOfReactants="1">
<specieReference specieID="39" name="mRNA(REP)" compartment="nucleoplasm" stoichiometry="1" cx="495" cy="670"/>
</listOfReactants>
<listOfProducts numberOfProducts="1">
<specieReference specieID="20" name="REP" compartment="nucleoplasm" stoichiometry="1" cx="495" cy="589"/>
</listOfProducts>
<lineLocation index="0" x1="495" y1="670" x2="495" y2="589" connectSegmentPoint="0"/>
</Reaction>
<Reaction reactionID="39" groupID="39" reactionType="transcription" isConvertible="true" reactionName="#39" isVisible="true" modifierReactionEquation="Gene(CYC) -&gt; mRNA(CYC)">
<listOfReactants numberOfReactants="1">
<specieReference specieID="49" name="Gene(CYC)" compartment="nucleoplasm" stoichiometry="1" cx="346" cy="397"/>
</listOfReactants>
<listOfProducts numberOfProducts="1">
<specieReference specieID="50" name="mRNA(CYC)" compartment="nucleoplasm" stoichiometry="1" cx="265" cy="383"/>
</listOfProducts>
<lineLocation index="0" x1="368" y1="383" x2="265" y2="383" connectSegmentPoint="0"/>
</Reaction>
<Reaction reactionID="40" groupID="40" reactionType="translation" isConvertible="true" reactionName="#40" isVisible="true" modifierReactionEquation="mRNA(CYC) -&gt; CYC">
<listOfReactants numberOfReactants="1">
<specieReference specieID="50" name="mRNA(CYC)" compartment="nucleoplasm" stoichiometry="1" cx="265" cy="383"/>
</listOfReactants>
<listOfProducts numberOfProducts="1">
<specieReference specieID="17" name="CYC" compartment="nucleoplasm" stoichiometry="1" cx="266" cy="331"/>
</listOfProducts>
<lineLocation index="0" x1="265" y1="383" x2="266" y2="331" connectSegmentPoint="0"/>
</Reaction>
</listOfReactions>
<listOfReactions layer="protein" numberOfReactions="13">
<Reaction reactionID="5" groupID="1" reactionType="homo_association_or_modification_with_stoichiometric_changes" isConvertible="true" reactionName="#5" isVisible="true" modifierReactionEquation="DBT -() PER + P &gt; PER-P">
<listOfReactants numberOfReactants="2">
<specieReference specieID="1" name="PER" compartment="cytoplasm" stoichiometry="1" cx="80" cy="696"/>
<specieReference specieID="59" name="P" compartment="cytoplasm" stoichiometry="1" cx="-1" cy="-1">
<lineLocation index="0" x1="0" y1="0" x2="0" y2="0" connectSegmentPoint="0"/>
</specieReference>
</listOfReactants>
<listOfProducts numberOfProducts="1">
<specieReference specieID="2" name="PER-P" compartment="cytoplasm" stoichiometry="1" cx="80" cy="382"/>
</listOfProducts>
<listOfModifiers numberOfModifiers="1">
<modifierSpecieReference specieID="8" name="DBT" compartment="cytoplasm" stoichiometry="1" cx="135" cy="431" modifierType="enzyme" isTotal="true">
<lineLocation index="0" x1="135" y1="431" x2="80" y2="587" connectSegmentPoint="0">
<segmentStatus counter="1" x="135" y="587"/>
</lineLocation>
</modifierSpecieReference>
</listOfModifiers>
<modifierComplex>
<specieReference specieID="10" name="PER:P:DBT" compartment="cytoplasm" stoichiometry="1" cx="-1" cy="-1"/>
</modifierComplex>
<lineLocation index="0" x1="80" y1="696" x2="80" y2="382" connectSegmentPoint="0"/>
</Reaction>
<Reaction reactionID="4" groupID="2" reactionType="homo_association_or_modification_with_stoichiometric_changes" isConvertible="true" reactionName="#4" isVisible="true" modifierReactionEquation="DBT -() PER-P + P &gt; PER-P-P">
<listOfReactants numberOfReactants="2">
<specieReference specieID="2" name="PER-P" compartment="cytoplasm" stoichiometry="1" cx="80" cy="382"/>
<specieReference specieID="59" name="P" compartment="cytoplasm" stoichiometry="1" cx="-1" cy="-1">
<lineLocation index="0" x1="0" y1="0" x2="0" y2="0" connectSegmentPoint="0"/>
</specieReference>
</listOfReactants>
<listOfProducts numberOfProducts="1">
<specieReference specieID="4" name="PER-P-P" compartment="cytoplasm" stoichiometry="1" cx="80" cy="66"/>
</listOfProducts>
<listOfModifiers numberOfModifiers="1">
<modifierSpecieReference specieID="8" name="DBT" compartment="cytoplasm" stoichiometry="1" cx="135" cy="431" modifierType="enzyme" isTotal="true">
<lineLocation index="0" x1="135" y1="431" x2="80" y2="274" connectSegmentPoint="0">
<segmentStatus counter="1" x="135" y="273"/>
</lineLocation>
</modifierSpecieReference>
</listOfModifiers>
<modifierComplex>
<specieReference specieID="9" name="PER-P:P:DBT" compartment="cytoplasm" stoichiometry="1" cx="-1" cy="-1"/>
</modifierComplex>
<lineLocation index="0" x1="80" y1="382" x2="80" y2="66" connectSegmentPoint="0"/>
</Reaction>
<Reaction reactionID="10" groupID="10" reactionType="binding" isConvertible="true" reactionName="#10" isVisible="true" modifierReactionEquation="CLK + CYC &lt;-&gt; CLK:CYC">
<listOfReactants numberOfReactants="2">
<specieReference specieID="16" name="CLK" compartment="nucleoplasm" stoichiometry="1" cx="738" cy="331">
<lineLocation index="0" x1="495" y1="331" x2="738" y2="331" connectSegmentPoint="0"/>
</specieReference>
<specieReference specieID="17" name="CYC" compartment="nucleoplasm" stoichiometry="1" cx="266" cy="331">
<lineLocation index="0" x1="495" y1="331" x2="266" y2="331" connectSegmentPoint="0"/>
</specieReference>
</listOfReactants>
<listOfProducts numberOfProducts="1">
<specieReference specieID="18" name="CLK:CYC" compartment="nucleoplasm" stoichiometry="1" cx="495" cy="331"/>
</listOfProducts>
<multiArmsReaction cx="495" cy="331"/>
</Reaction>
<Reaction reactionID="11" groupID="11" reactionType="binding" isConvertible="true" reactionName="#11" isVisible="true" modifierReactionEquation="CLK:CYC + PER-N-TIM &lt;-&gt; CLK:CYC:PER-N-TIM">
<listOfReactants numberOfReactants="2">
<specieReference specieID="18" name="CLK:CYC" compartment="nucleoplasm" stoichiometry="1" cx="495" cy="331">
<lineLocation index="0" x1="495" y1="252" x2="495" y2="331" connectSegmentPoint="0"/>
</specieReference>
<specieReference specieID="57" name="PER-N-TIM" compartment="nucleoplasm" stoichiometry="1" cx="495" cy="165">
<lineLocation index="0" x1="495" y1="252" x2="495" y2="165" connectSegmentPoint="0"/>
</specieReference>
</listOfReactants>
<listOfProducts numberOfProducts="1">
<specieReference specieID="19" name="CLK:CYC:PER-N-TIM" compartment="nucleoplasm" stoichiometry="1" cx="495" cy="252"/>
</listOfProducts>
<multiArmsReaction cx="495" cy="252"/>
</Reaction>
<Reaction reactionID="12" groupID="12" reactionType="binding" isConvertible="true" reactionName="#12" isVisible="true" modifierReactionEquation="CLK:CYC + REP &lt;-&gt; CLK:CYC:REP">
<listOfReactants numberOfReactants="2">
<specieReference specieID="18" name="CLK:CYC" compartment="nucleoplasm" stoichiometry="1" cx="495" cy="331">
<lineLocation index="0" x1="495" y1="489" x2="495" y2="331" connectSegmentPoint="0"/>
</specieReference>
<specieReference specieID="20" name="REP" compartment="nucleoplasm" stoichiometry="1" cx="495" cy="589">
<lineLocation index="0" x1="495" y1="489" x2="495" y2="589" connectSegmentPoint="0"/>
</specieReference>
</listOfReactants>
<listOfProducts numberOfProducts="1">
<specieReference specieID="21" name="CLK:CYC:REP" compartment="nucleoplasm" stoichiometry="1" cx="495" cy="489"/>
</listOfProducts>
<multiArmsReaction cx="495" cy="489"/>
</Reaction>
<Reaction reactionID="20" groupID="20" reactionType="binding" isConvertible="true" reactionName="#20" isVisible="true" modifierReactionEquation="10CLK:CYC + Enhancer(PER) &lt;-&gt; CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:Enhancer(PER)">
<listOfReactants numberOfReactants="2">
<specieReference specieID="18" name="CLK:CYC" compartment="nucleoplasm" stoichiometry="10" cx="495" cy="331">
<lineLocation index="0" x1="392" y1="491" x2="495" y2="331" connectSegmentPoint="0">
<segmentStatus counter="1" x="392" y="425"/>
</lineLocation>
</specieReference>
<specieReference specieID="28" name="Enhancer(PER)" compartment="nucleoplasm" stoichiometry="1" cx="305" cy="535">
<lineLocation index="0" x1="392" y1="491" x2="305" y2="535" connectSegmentPoint="0">
<segmentStatus counter="1" x="305" y="491"/>
</lineLocation>
</specieReference>
</listOfReactants>
<listOfProducts numberOfProducts="1">
<specieReference specieID="29" name="CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:Enhancer(PER)" compartment="nucleoplasm" stoichiometry="1" cx="392" cy="491"/>
</listOfProducts>
<multiArmsReaction cx="392" cy="491"/>
</Reaction>
<Reaction reactionID="24" groupID="24" reactionType="binding" isConvertible="true" reactionName="#24" isVisible="true" modifierReactionEquation="10CLK:CYC + Enhancer(TIM) &lt;-&gt; CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:Enhancer(TIM)">
<listOfReactants numberOfReactants="2">
<specieReference specieID="18" name="CLK:CYC" compartment="nucleoplasm" stoichiometry="10" cx="495" cy="331">
<lineLocation index="0" x1="590" y1="211" x2="495" y2="331" connectSegmentPoint="0">
<segmentStatus counter="1" x="540" y="211"/>
</lineLocation>
</specieReference>
<specieReference specieID="30" name="Enhancer(TIM)" compartment="nucleoplasm" stoichiometry="1" cx="590" cy="283">
<lineLocation index="0" x1="590" y1="211" x2="590" y2="283" connectSegmentPoint="0"/>
</specieReference>
</listOfReactants>
<listOfProducts numberOfProducts="1">
<specieReference specieID="31" name="CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:Enhancer(TIM)" compartment="nucleoplasm" stoichiometry="1" cx="590" cy="211"/>
</listOfProducts>
<multiArmsReaction cx="590" cy="211"/>
</Reaction>
<Reaction reactionID="35" groupID="35" reactionType="binding" isConvertible="true" reactionName="#35" isVisible="true" modifierReactionEquation="PER-P-P + TIM &lt;-&gt; PER-P-P:TIM">
<listOfReactants numberOfReactants="2">
<specieReference specieID="4" name="PER-P-P" compartment="cytoplasm" stoichiometry="1" cx="80" cy="66">
<lineLocation index="0" x1="495" y1="66" x2="80" y2="66" connectSegmentPoint="0"/>
</specieReference>
<specieReference specieID="6" name="TIM" compartment="cytoplasm" stoichiometry="1" cx="719" cy="66">
<lineLocation index="0" x1="495" y1="66" x2="719" y2="66" connectSegmentPoint="0"/>
</specieReference>
</listOfReactants>
<listOfProducts numberOfProducts="1">
<specieReference specieID="42" name="PER-P-P:TIM" compartment="cytoplasm" stoichiometry="1" cx="495" cy="66"/>
</listOfProducts>
<multiArmsReaction cx="495" cy="66"/>
</Reaction>
<Reaction reactionID="37" groupID="37" reactionType="binding" isConvertible="true" reactionName="#37" isVisible="true" modifierReactionEquation="10CLK:CYC:REP + Promoter(CLK) &lt;-&gt; CLK:CYC:REP:CLK:CYC:REP:CLK:CYC:REP:CLK:CYC:REP:CLK:CYC:REP:CLK:CYC:REP:CLK:CYC:REP:CLK:CYC:REP:CLK:CYC:REP:CLK:CYC:REP:Promoter(CLK)">
<listOfReactants numberOfReactants="2">
<specieReference specieID="21" name="CLK:CYC:REP" compartment="nucleoplasm" stoichiometry="10" cx="495" cy="489">
<lineLocation index="0" x1="610" y1="489" x2="495" y2="489" connectSegmentPoint="0"/>
</specieReference>
<specieReference specieID="22" name="Promoter(CLK)" compartment="nucleoplasm" stoichiometry="1" cx="610" cy="542">
<lineLocation index="0" x1="610" y1="489" x2="610" y2="542" connectSegmentPoint="0"/>
</specieReference>
</listOfReactants>
<listOfProducts numberOfProducts="1">
<specieReference specieID="45" name="CLK:CYC:REP:CLK:CYC:REP:CLK:CYC:REP:CLK:CYC:REP:CLK:CYC:REP:CLK:CYC:REP:CLK:CYC:REP:CLK:CYC:REP:CLK:CYC:REP:CLK:CYC:REP:Promoter(CLK)" compartment="nucleoplasm" stoichiometry="1" cx="610" cy="489"/>
</listOfProducts>
<multiArmsReaction cx="610" cy="489"/>
</Reaction>
<Reaction reactionID="9" groupID="43" reactionType="irreversible_conversion" isConvertible="true" reactionName="#9" isVisible="true" modifierReactionEquation="CHAN -() PER-P-P:TIM &gt; PER-N-TIM">
<listOfReactants numberOfReactants="1">
<specieReference specieID="42" name="PER-P-P:TIM" compartment="cytoplasm" stoichiometry="1" cx="495" cy="66"/>
</listOfReactants>
<listOfProducts numberOfProducts="1">
<specieReference specieID="57" name="PER-N-TIM" compartment="nucleoplasm" stoichiometry="1" cx="495" cy="165"/>
</listOfProducts>
<listOfModifiers numberOfModifiers="1">
<modifierSpecieReference specieID="12" name="CHAN" compartment="nucleoplasm" stoichiometry="1" cx="425" cy="141" modifierType="enzyme" isTotal="true">
<lineLocation index="0" x1="425" y1="141" x2="495" y2="101" connectSegmentPoint="0">
<segmentStatus counter="1" x="425" y="101"/>
</lineLocation>
</modifierSpecieReference>
</listOfModifiers>
<modifierComplex>
<specieReference specieID="58" name="PER-P-P:TIM:CHAN" compartment="nucleoplasm" stoichiometry="1" cx="-1" cy="-1"/>
</modifierComplex>
<lineLocation index="0" x1="495" y1="66" x2="495" y2="165" connectSegmentPoint="0"/>
</Reaction>
<Reaction reactionID="44" groupID="44" reactionType="degradation" isConvertible="true" reactionName="#44" isVisible="true" modifierReactionEquation="PER-P-P -&gt; &amp;">
<listOfReactants numberOfReactants="1">
<specieReference specieID="4" name="PER-P-P" compartment="cytoplasm" stoichiometry="1" cx="80" cy="66"/>
</listOfReactants>
<lineLocation index="0" x1="80" y1="66" x2="46" y2="66" connectSegmentPoint="0"/>
</Reaction>
<Reaction reactionID="45" groupID="45" reactionType="degradation" isConvertible="true" reactionName="#45" isVisible="true" modifierReactionEquation="PER-P -&gt; &amp;">
<listOfReactants numberOfReactants="1">
<specieReference specieID="2" name="PER-P" compartment="cytoplasm" stoichiometry="1" cx="80" cy="382"/>
</listOfReactants>
<lineLocation index="0" x1="80" y1="382" x2="41" y2="382" connectSegmentPoint="0"/>
</Reaction>
<Reaction reactionID="47" groupID="47" reactionType="degradation" isConvertible="true" reactionName="#47" isVisible="true" modifierReactionEquation="PER-N-TIM -&gt; &amp;">
<listOfReactants numberOfReactants="1">
<specieReference specieID="57" name="PER-N-TIM" compartment="nucleoplasm" stoichiometry="1" cx="495" cy="165"/>
</listOfReactants>
<lineLocation index="0" x1="495" y1="165" x2="555" y2="165" connectSegmentPoint="0"/>
</Reaction>
</listOfReactions>
</model>
</sanac>
