##### Model ################ # TITLE:Drosophila-Circadian # INFO: # CONVERSION TYPE # GENE-PROTEIN:TPP_RAPID # METABOLIC:NONE N_VAR ; 40; # num of variables(all) N_ALGEBR; 23; # num of variables(Algebraic Eq) #Y_START ; index; initial_value; tag #comment Y_START ; 1; 3.5729e-08; PER.cyt # Y_START ; 2; 2.4858e-08; PER-P.cyt # Y_START ; 3; 1.5501e-10; PER-P-P.cyt # Y_START ; 4; 1.7320e-07; TIM.cyt # Y_START ; 5; 1.4167e-08; DBT.cyt # Y_START ; 6; 6.9951e-08; CHAN.nuc # Y_START ; 7; 3.1562e-09; CLK.nuc # Y_START ; 8; 1.3638e-07; CYC.nuc # Y_START ; 9; 3.3863e-09; REP.nuc # Y_START ; 10; 6.6711e-10; Promoter(CLK).nuc # Y_START ; 11; 8.1728e-10; Enhancer(PER).nuc # Y_START ; 12; 8.1728e-10; Enhancer(TIM).nuc # Y_START ; 13; 2.7950e-08; PER-N-TIM.nuc # Y_START ; 14; 3.5217e-08; PER-P:P:DBT.cyt # Y_START ; 15; 5.0617e-08; PER:P:DBT.cyt # Y_START ; 16; 4.3044e-08; CLK:CYC.nuc # Y_START ; 17; 1.2031e-07; CLK:CYC:PER-N-TIM.nuc # Y_START ; 18; 9.3285e-08; CLK:CYC:REP.nuc # Y_START ; 19; 1.8272e-10; CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:Enhancer(PER).nuc # Y_START ; 20; 1.8272e-10; CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:Enhancer(TIM).nuc # Y_START ; 21; 4.2958e-09; PER-P-P:TIM.cyt # Y_START ; 22; 3.3289e-10; CLK:CYC:REP:CLK:CYC:REP:CLK:CYC:REP:CLK:CYC:REP:CLK:CYC:REP:CLK:CYC:REP:CLK:CYC:REP:CLK:CYC:REP:CLK:CYC:REP:CLK:CYC:REP:Promoter(CLK).nuc # Y_START ; 23; 3.0049e-08; PER-P-P:TIM:CHAN.nuc # Y_START ; 24; 2.6569e-08; mRNA(CLK).nuc # Y_START ; 25; 4.9476e-08; mRNA(PER).nuc # Y_START ; 26; 4.9476e-08; mRNA(TIM).nuc # Y_START ; 27; 1.0000e-08; mRNA(DBT).nuc # Y_START ; 28; 1.0000e-08; mRNA(CHAN).nuc # Y_START ; 29; 1.0000e-08; mRNA(REP).nuc # Y_START ; 30; 4.0000e-08; mRNA(CYC).nuc # Y_START ; 31; 8.6370e-08; TPER.cyt # Y_START ; 32; 6.0155e-08; TPER-P.cyt # Y_START ; 33; 3.4539e-08; TPER-P-P.cyt # Y_START ; 34; 2.0783e-07; TTIM.cyt # Y_START ; 35; 1.0000e-07; TDBT.cyt # Y_START ; 36; 1.0000e-07; TCHAN.nuc # Y_START ; 37; 2.6677e-07; TCLK.nuc # Y_START ; 38; 4.0000e-07; TCYC.nuc # Y_START ; 39; 1.0000e-07; TREP.nuc # Y_START ; 40; 1.4848e-07; TPER-N-TIM.nuc # #PARAM;name;index;val;val_start;num_survey;D/R/S;change-val;GA_min;GA_max;tag #comment PARAM ;constantPlayer; 1; 1e-09;;0;D;;;; Gene(CLK).nuc # PARAM ;constantPlayer; 2; 1e-09;;0;D;;;; Gene(PER).nuc # PARAM ;constantPlayer; 3; 1e-09;;0;D;;;; Gene(TIM).nuc # PARAM ;constantPlayer; 4; 1e-09;;0;D;;;; Gene(DBT).nuc # PARAM ;constantPlayer; 5; 1e-09;;0;D;;;; Gene(CHAN).nuc # PARAM ;constantPlayer; 6; 1e-09;;0;D;;;; Gene(REP).nuc # PARAM ;constantPlayer; 7; 1e-09;;0;D;;;; Gene(CYC).nuc # PARAM ;constantPlayer; 8; 1;;0;D;;;; P.cyt # PARAM ;constantPlayer; 9; 1e-09;;0;D;;;; TPromoter(CLK).nuc # PARAM ;constantPlayer; 10; 1e-09;;0;D;;;; TEnhancer(PER).nuc # PARAM ;constantPlayer; 11; 1e-09;;0;D;;;; TEnhancer(TIM).nuc # PARAM ;Kb ; 1; 1e+08;;0;D;;;; binding_constant_DBT.cyt_P.cyt_PER.cyt # PARAM ;Kb ; 2; 1e+08;;0;D;;;; binding_constant_DBT.cyt_P.cyt_PER-P.cyt # PARAM ;Kb ; 3; 1e+08;;0;D;;;; binding_constant_CLK.nuc_CYC.nuc # PARAM ;Kb ; 4; 1e+08;;0;D;;;; binding_constant_CLK:CYC.nuc_PER-N-TIM.nuc # PARAM ;Kb ; 5; 6.4e+08;;0;D;;;; binding_constant_CLK:CYC.nuc_REP.nuc # PARAM ;Kb ; 6; 2e+07;;0;D;;;; binding_constant_CLK:CYC.nuc_Enhancer(PER).nuc # PARAM ;Kb ; 7; 2e+07;;0;D;;;; binding_constant_CLK:CYC.nuc_Enhancer(TIM).nuc # PARAM ;Kb ; 8; 1.6e+08;;0;D;;;; binding_constant_PER-P-P.cyt_TIM.cyt # PARAM ;Kb ; 9; 1e+07;;0;D;;;; binding_constant_CLK:CYC:REP.nuc_Promoter(CLK).nuc # PARAM ;Kb ; 10; 1e+08;;0;D;;;; binding_constant_CHAN.nuc_PER-P-P:TIM.cyt # PARAM ;kx ; 1; 0.8;;0;D;;;; reaction_rate_constant_DBT.cyt_P.cyt_PER.cyt # PARAM ;kx ; 2; 0.8;;0;D;;;; reaction_rate_constant_DBT.cyt_P.cyt_PER-P.cyt # PARAM ;kx ; 3; 0.8;;0;D;;;; reaction_rate_constant_CHAN.nuc_PER-P-P:TIM.cyt # PARAM ;kx ; 4; 0.2;;0;D;;;; reaction_rate_constant_PER-P-P.cyt # PARAM ;kx ; 5; 0.2;;0;D;;;; reaction_rate_constant_PER-P.cyt # PARAM ;kx ; 6; 0.2;;0;D;;;; reaction_rate_constant_PER-N-TIM.nuc # PARAM ;kp ; 1; 1;;0;D;;;; translation_rate_constant_mRNA(CLK).nuc # PARAM ;kp ; 2; 1;;0;D;;;; translation_rate_constant_mRNA(PER).nuc # PARAM ;kp ; 3; 1;;0;D;;;; translation_rate_constant_mRNA(TIM).nuc # PARAM ;kp ; 4; 1;;0;D;;;; translation_rate_constant_mRNA(DBT).nuc # PARAM ;kp ; 5; 1;;0;D;;;; translation_rate_constant_mRNA(CHAN).nuc # PARAM ;kp ; 6; 1;;0;D;;;; translation_rate_constant_mRNA(REP).nuc # PARAM ;kp ; 7; 1;;0;D;;;; translation_rate_constant_mRNA(CYC).nuc # PARAM ;kpd ; 1; 0.1;;0;D;;;; decomposition_rate_constant_PER.cyt # PARAM ;kpd ; 2; 0.1;;0;D;;;; decomposition_rate_constant_PER-P.cyt # PARAM ;kpd ; 3; 0.1;;0;D;;;; decomposition_rate_constant_PER-P-P.cyt # PARAM ;kpd ; 4; 0.1;;0;D;;;; decomposition_rate_constant_TIM.cyt # PARAM ;kpd ; 5; 0.1;;0;D;;;; decomposition_rate_constant_DBT.cyt # PARAM ;kpd ; 6; 0.1;;0;D;;;; decomposition_rate_constant_CHAN.nuc # PARAM ;kpd ; 7; 0.1;;0;D;;;; decomposition_rate_constant_CLK.nuc # PARAM ;kpd ; 8; 0.1;;0;D;;;; decomposition_rate_constant_CYC.nuc # PARAM ;kpd ; 9; 0.1;;0;D;;;; decomposition_rate_constant_REP.nuc # PARAM ;kpd ; 10; 0.1;;0;D;;;; decomposition_rate_constant_PER-N-TIM.nuc # PARAM ;kpd ; 11; 0.1;;0;D;;;; decomposition_rate_constant_PER-P:P:DBT.cyt # PARAM ;kpd ; 12; 0.1;;0;D;;;; decomposition_rate_constant_PER:P:DBT.cyt # PARAM ;kpd ; 13; 0.1;;0;D;;;; decomposition_rate_constant_CLK:CYC.nuc # PARAM ;kpd ; 14; 0.1;;0;D;;;; decomposition_rate_constant_CLK:CYC:PER-N-TIM.nuc # PARAM ;kpd ; 15; 0.1;;0;D;;;; decomposition_rate_constant_CLK:CYC:REP.nuc # PARAM ;kpd ; 16; 0.1;;0;D;;;; decomposition_rate_constant_CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:Enhancer(PER).nuc # PARAM ;kpd ; 17; 0.1;;0;D;;;; decomposition_rate_constant_CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:Enhancer(TIM).nuc # PARAM ;kpd ; 18; 0.1;;0;D;;;; decomposition_rate_constant_PER-P-P:TIM.cyt # PARAM ;kpd ; 19; 0.1;;0;D;;;; decomposition_rate_constant_CLK:CYC:REP:CLK:CYC:REP:CLK:CYC:REP:CLK:CYC:REP:CLK:CYC:REP:CLK:CYC:REP:CLK:CYC:REP:CLK:CYC:REP:CLK:CYC:REP:CLK:CYC:REP:Promoter(CLK).nuc # PARAM ;kpd ; 20; 0.1;;0;D;;;; decomposition_rate_constant_PER-P-P:TIM:CHAN.nuc # PARAM ;km ; 1; 4;;0;D;;;; transcription_rate_constant_CLK:CYC:REP:CLK:CYC:REP:CLK:CYC:REP:CLK:CYC:REP:CLK:CYC:REP:CLK:CYC:REP:CLK:CYC:REP:CLK:CYC:REP:CLK:CYC:REP:CLK:CYC:REP:Promoter(CLK).nuc_Gene(CLK).nuc # PARAM ;km ; 2; 16;;0;D;;;; transcription_rate_constant_CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:Enhancer(PER).nuc_Gene(PER).nuc # PARAM ;km ; 3; 16;;0;D;;;; transcription_rate_constant_CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:CLK:CYC:Enhancer(TIM).nuc_Gene(TIM).nuc # PARAM ;km ; 4; 1;;0;D;;;; transcription_rate_constant_Gene(DBT).nuc # PARAM ;km ; 5; 1;;0;D;;;; transcription_rate_constant_Gene(CHAN).nuc # PARAM ;km ; 6; 1;;0;D;;;; transcription_rate_constant_Gene(REP).nuc # PARAM ;km ; 7; 4;;0;D;;;; transcription_rate_constant_Gene(CYC).nuc # PARAM ;kmd ; 1; 0.1;;0;D;;;; decomposition_rate_constant_mRNA(CLK).nuc # PARAM ;kmd ; 2; 0.1;;0;D;;;; decomposition_rate_constant_mRNA(PER).nuc # PARAM ;kmd ; 3; 0.1;;0;D;;;; decomposition_rate_constant_mRNA(TIM).nuc # PARAM ;kmd ; 4; 0.1;;0;D;;;; decomposition_rate_constant_mRNA(DBT).nuc # PARAM ;kmd ; 5; 0.1;;0;D;;;; decomposition_rate_constant_mRNA(CHAN).nuc # PARAM ;kmd ; 6; 0.1;;0;D;;;; decomposition_rate_constant_mRNA(REP).nuc # PARAM ;kmd ; 7; 0.1;;0;D;;;; decomposition_rate_constant_mRNA(CYC).nuc # #T_EVENT ; name; index; time; value; #comment ######## Don't edit the following lines. ###### PARAM_NAME ;constantPlayer # PARAM_NAME ;Kb # PARAM_NAME ;kx # PARAM_NAME ;kp # PARAM_NAME ;kpd # PARAM_NAME ;km # PARAM_NAME ;kmd #